Cats

Interpretation of Creatinine 2.3 mg/dL in Cats

A creatinine concentration of 2.3 mg/dL places a cat in IRIS CKD Stage 2 (1.6–2.8 mg/dL), indicating mild azotemia in a stable, well-hydrated patient .

Stage 2 cats are often asymptomatic or show only mild signs such as increased thirst and urination (polyuria/polydipsia), subtle appetite changes, weight loss or occasional lethargy ([thevetiverse.com][1]).

Influence of Muscle Mass

Creatinine is produced by muscle metabolism, so a larger‐framed or more muscular cat may have a higher baseline level of creatinine independent of kidney function (IRIS↗).

In such cases, it’s important to interpret creatinine alongside other markers—symmetric dimethylarginine (SDMA), urine specific gravity (USG), blood urea nitrogen (BUN) and hydration status—to distinguish true renal impairment from muscle-related elevations.

Potential Consequences and Management

• progressive decline in glomerular filtration rate if underlying kidney disease exists
• risk of accumulating waste products (uremia) over time
• potential for hypertension and proteinuria as CKD advances

To mitigate progression:

• monitor renal bloodwork (creatinine, SDMA) and USG every 3–6 months
• feed a veterinary‐formulated renal diet (phosphorus restriction)
• encourage free access to fresh water or use subcutaneous fluids if needed
• measure blood pressure and screen for proteinuria to guide therapy

Consult your veterinarian for a full workup—including repeat blood tests, urinalysis, blood pressure measurement and imaging—to confirm CKD, rule out pre-renal causes (e.g., dehydration) and develop a tailored management plan.

Disclaimer: This information is for educational purposes and does not replace professional veterinary advice.

[1]: https://www.thevetiverse.com/en/latest/iris-staging-of-chronic-kidney-disease-in-pets-for-improved-outcomes/↗ "

IRIS Staging of Chronic Kidney Disease in Pets for Improved Outcomes - The Vetiverse

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